A Preliminary Study on Possible Effects of Mitomycin-C on the Collagen Content of Penis in Rat

Peyronie’s disease (PD) involves localized fibrotic plaque formation in the penile tunica albuginea (TA), leading to curvature of the erect penis and often to pain and/or erectile dysfunction, and affecting 9% of men [1-3]. The primary reason for this and the cause of the PD plaque is unknown and the molecular pathology is poorly understood, although it is thought that often the plaque develops as the result of an abnormal wound healing process after a TA trauma [4-6]. Peyronie’s disease is characterized by development of a fibrotic plaque [7]. After the trauma fibrin triggers fibroblast activation and proliferation that results in excessive deposition of extracellular collagen matrix in the tunica albuginea [8-10]. The formation of excessive fibrous tissue may also be triggered in genetically predisposed individuals, either from abnormal fibroblastic activity or decreased fibrinolysis [9,10].